||The purpose of this study was carried out by the embryotoxicity risk assessment of the dental alloys containing indium. We produced Ag-In alloy, Ag-Pd-Au-Cu alloy and gold alloy for porcelain bonding. For the extraction of these alloy components into the ES-D3 cell culture medium, each alloy was reduced to a powder using a diamond point and sterilized after rinsing. In order to facilitate the extraction, each alloy powder was subjected to extraction together with diamond powder using a rotary stirrer. Two-fold diluted test medium was used to estimate the presence of embryotoxicity from the differentiation rate of EBs in the extract. Our test results this time suggest that 35Ag-30Pd-20Au-15Cu alloys and gold alloys for porcelain bonding involve virtually no embryotoxicity risk. On the other hand, the alloy of silver and 20% indium may require further examination.